Many people are battling weight gain. When you have already eaten there is this tendency for one to overeat.
The body then has to turn these extra calories into fat. Imagine a drug that that tells your body that you are full when you are not.
It goes ahead and helps your body burn that extra fat, leaving you with that perfect body you have always dreamed of. Fexaramine is your modern solution to that weight problem.
Fexaramine has been designed by Salk Institute for Biological Studies in the US.
The company has had an expansive experience with AIDS and Alzheimer. The drug, though not available commercially, was first tested on obese mice.
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Fexaramine unlike other drugs does not go to the body system but is absorbed in the intestines.
During the test the mice were observed to burn calories just like they had eaten. The drug made the mice think that they were full hence consuming less food.
How does Fexaramine Work?
Fexaramine once in the body triggers the farnesoid X receptor (FXR). Once this is switched the body produces natural occurring acids called bile.
This is the acid that is used digest the food that we eat. Fexaramine tricks the body to think that it has consumed food.
You will then feel full and avoid taking that extra burger. Your body also immediately starts burning excess fat.
Fexaramine easily acts as a receptor for FXR. Once it binds to FXR certain chain reactions are created in the body.
Digestion begins followed by a high metabolic rate which results in lower cholesterol. FXR is mainly found in the liver and intestines.
How doe Fexaramine work in the body?
- Fat Burning
The drug primarily does this through a process called thermogenesis.
This is a process where the body temperature is raised to a certain degree which then results in the body burning stored fat so as to maintain this temperature.
This leads to rapid burning of excess body fat.
Fexaramine also determines how the body stores different fats; white and brown fat. White fat tends to be very hard to burn down, unlike brown fat.
The drug has been noted to increase the production of brown fat in the body which can be easily converted to energy in the body.
Since the drug reduces your calorie intake your body is forced to utilize stored fat in the body due to lack of extra calories. This leads to reduced weight gain.
- Loss of Appetite
This is the key benefit of the drug. It is able to trick your body to think that you are full hence reduce your intake of calories.
Most of the time we continue eating until we have a feeling of being full.
When your body receives fewer calories it has to convert existing fat stores to get much-needed energy reserves, which eventually leads to gradual weight loss.
The drug has also been noted to reduce blood glucose in the body. When blood glucose is reduced in the body you tend to have lower appetite, which results in you having lower sugar cravings.
We tend to put more weight when we add unhealthy sugars into our body. The body is then forced to convert these sugars into fat hence resulting in weight gain.
- Increased metabolism rate in the Body
As discussed earlier through the process of thermogenesis the drug is able to increase the body temperature.
These increased degrees often result in a higher metabolic rate in the body. To maintain this high temperature your body burns more fat.
The drug has been also noted to increase bile production in the body which helps in metabolism.
Success rates of Fexaramine
Although the drug has only been tested on mice, there is a high chance that it leads to weight loss on human beings. Salk Institute is a reputable company and they have had a lot of success in AIDS trials.
Tests done on mice have been hugely successful with mice reporting lower appetites. The drug is noted not to cause any side effects as it goes to the intestines instead of the bloodstream.
It is yet to be seen how well fexaramine will work on humans as other supplements to have dangerous side effects.
But, the drug will be a suitable alternative to surgery. The drug is expected to spur a lot of debate in the diet supplement industry where there have been a lot of counterfeits.
This is one of the best fat burners in the market today. The supplement is gotten from the Garcinia Cambogia fruit, a popular fruit in Southeast Asia.
Hydroxycritic acid found in the fruit is what is used for weight loss. Garcinia function in the body is twofold; first it suppresses appetite then it prevents accumulation of fat in the body.
The fruit is known to be rich in Calcium, Phosphorous, iron, riboflavin, thiamine and niacin.
This been a supplement it is not regulated by the Food and Drug Administration (FDA), making it up to the manufacturers to determine how much of Garcinia extract to use.
The Garcinia fruit itself is very sour but many people use it for food flavouring.
It is the peel where the fruit finds its most important use; hydroxycritic acid.
In some communities in Malaysia, the fruit is used to make a soup that is eaten before meals because it suppresses appetite.
Studies done on mice have discovered that when consumed the mice ate less, lost some weight and less fat was converted into fat.
While for humans results have not been totally conclusive it has been noted to have a drastic loss in weight among some people.
The main ingredient in garcinia is HCA and it works by blocking adenosine triphosphate citrate an enzyme responsible for the formation of fat cells.
By inhibiting citrate lyase there is a slowdown in fat production in the body.
The downside is some people have reported having gastrointestinal adverse effects after coming into contact with HCA.
There is, however, more research been conducted on garcinia effect on weight loss. Studies on humans have noted that HCA can lead to lower levels of fats and reduce oxidative stress in the body. Another study showed that garcinia can lead to a considerable reduction in the accumulation of belly fat in overweight people.
A study of obese people revealed that obese individuals who were given garcinia for eight weeks had the following reduced risks of the following:
- Total Cholesterol levels were reduced by 6.3 per cent
- LDL the bad cholesterol was 12.5 per cent lower
- The good cholesterol levels rose by 10.3 per cent
- Blood triglycerides were 10.7 per cent higher
- More than 125 to 128 per cent of fat metabolites was excreted in the urine
HCA in garcinia helps to the body produce serotonin. This is a feel-good hormone in the body that is responsible for happy feelings.
Once serotonin is released a person experiences fewer cravings and a reduction in desire for luxury foods.
Some people who experience weight gain tend to be in depressed moods and in an effort to snap out of it they consume a lot of junk food. With serotonin in the body, you feel happy and calm.
There is evidence of garcinia improving cholesterol levels and lowering triglycerides. HCA is known to increase the production of good cholesterol (HDL) in the body while at the same time lowering the bad cholesterol.
It was noted that there was more excretion of fat metabolites in the urine of those taking the drug. By inhibiting citrate lyase garcinia helps reduce a blood fat which eventually leads to low weight gain.
High blood fats are the number one reason for weight problems in many people. The drug may however not be suitable to people with low blood sugar as there levels are already low.
Stabilizing Blood sugar
Garcinia is believed to help control blood sugar by helping cells absorb glucose better.
This is done by inhibiting pancreatic amylase enzymes and altering synthesis of fatty acids. This in return helps the body respond to insulin better. The drug may not be suitable for diabetic people who already battling with low blood sugar.
Who can use Garcinia
The medication is not suitable for those who are breastfeeding or pregnant as HCA may have negative side effects.
For those with diabetes, they may need to consult their doctor before taking the drug as it can lead to a drop in sugar levels.
What are the side effects of using Garcinia
When not used well it may result to liver damage. Other side effects include:
- Fatigue and brain fog
- Skin Rashes
- Diarrhoea, indigestion or nausea
- You may become dizzy or feel weak
The drug may interact with other drugs and it is therefore not recommended for the following people:
- Women who are pregnant or who are breastfeeding
- People with existing liver conditions like cirrhosis
- Asthmatic and people on various allergic medications
- It may interrupt insulin levels in diabetic people
- People who are anaemic and who may be taking iron supplements
- People who are taking various mental health medications for depression, bipolar, panic and anxiety attacks
- People on drugs to lower cholesterol or blood thinning
When purchasing any garcinia supplement care should be taken to see how much HCA is in included. The recommended dosage is usually 50 to 60 per cent of the product. Weight loss supplements should include other methods like exercise or low-calorie diets.
Comparison between Fexaramine and Garcinia
Garcinia Extra has been in the market for some time and there are various supplements pills that use the garcinia extract.
However, Fexaramine use has been only been available for clinical trials on mice, no conclusive usage has been reported in humans.
|Mechanism of Action||Inhibits the receptor FXR which leads to a high metabolic rate. The body thinks it has eaten and starts converting stored fats into energy.||Leads to production of HCA a component essential for preventing the conversion of calories to fats.|
|Once in the body feel as if you are full hence you consume fewer sugars. You also experience a loss of appetite.||HCA promotes the production of serotonin, which makes the user feel happy and leads to a loss of appetite|
|Absorption in the Body||This is through the intestines||Absorbed through the blood|
|Side Effects||They are not known side effects mainly because it is absorbed in the intestines and not in the blood,||Although it’s 100% natural ingredient (without chemicals nor fillers) there are RARE side effects:|
· Fatigue and brain fog
· Skin rashes
· Diarrhea, indigestion or nausea
· You may become dizzy or feel weak
|Who Can take it||Trials have so far been done on mice but more conclusive results are needed on humans||It may not be suitable for the following people:|
· Women who are pregnant or who are breastfeeding
· People with existing liver conditions like cirrhosis
· Asthmatic and people on various allergic medications
· It may interrupt insulin levels in diabetic people
· People who are anemic and who may be taking iron supplements
|Prescription needed||The drug has yet to be made available to humans||This is an over the counter drug. Though you should seek medical advice if you are using other medications.|
|Availability||Not yet available in the market||Available on Garciniaextra.com|
Similarities between Fexaramine and Garcinia Extra
The above drugs have been noted to greatly reduce appetite hence leading to people consuming less food. The drugs are psychological drugs that trick the brain to think you are full when you are not. It should be noted that what we consume most are snacks, which tend to be high in calories.
This, when absorbed in the body, is easily stored as fats leading to weight gain. Unhealthy fats lead to high cholesterol levels and may eventually cause health problems like diabetes.
Both of the drugs lead to the production of good fats and reduction of bad fats in the body.
By increasing metabolism in the body, fat is converted into energy.
This conversion reduces the accumulation of belly fat in most obese people. Clinical tests done on mice have shown a considerable reduction in weight when either drugs are administered.
There is still need for conclusive research on the effects of both drugs in weight loss.
Fexaramine is relatively new and has not been tested on humans so very few studies have been conducted to determine its effects on humans.
The major difference between the two drugs has been how they are absorbed by the body. While Fexaramine is absorbed in the intestines, garcinia is absorbed into the blood. Fexaramine is still not available in the market and people will have to have a wait and see attitude.
Why you should purchase Garcinia
Garcinia is highly recommended for obese and people who want to reduce weight. It is recommended to take 2,800 mg of HCA per day.
The Garcinia supplements are not regulated by Food and Drug Administration (FDA), therefore great care is needed to ensure that recommended dosage is followed.
You should also consult your physician before purchasing the drug as it is known to interact with other drugs. Some common side effects include digestive symptoms, headaches and skin rashes. If symptoms persist seek medical help.
Further studies on animals have shown that garcinia can affect sperm production with shrinking testicles. High intakes on animals were shown to cause toxicity.
It is recommended to take 500mg, three times a day and 30 to 50 minutes before meals. Always check that the HCA is between 50 and 60 percent.
We all want that perfect body and losing weight is one way to do this.
There are many supplements out there that promise instant results but leave you disappointed.
Fexaramine promises to be a very interesting drug but till clinical tests are conducted on humans the drug will remain off the shelf.
Garcinia is a recommended drug that lowers your appetite hence reducing consumption of harmful calories.
We all like taking bites off chocolate bars anytime we feel hungry. This drug by suppressing this appetite will help you lose weight. There has been extensive research on the drug and the results have been amazing.
However, you should add other weight loss programs like going to the gym and eating healthy food. Supplements should not be the only way to lose weight, simple ways like using the stairs and taking short walks should also be included.
Unlike Fexaramine, Garcinia is widely available in various online stores and you can also find it in your convenience store. Always seek medical opinion if you are on other medications.